AstraZeneca is the worst performer in the Footsie because the FDA has asked for more information about blood-thinning drug Brilinta.This represents a further delay is getting US approval for Brilinta.Gloomy comments by the Bank of England about potential bad debt provisions hit Royal Bank of Scotland, Lloyds and Barclays. A cut in Ireland's credit rating from Aa2 to Baa1 by Moody's has not helped. A positive trading statement was not enough to prevent the Aggreko share price from falling. Property companies are higher after Credit Suisse upgraded its recommendation for the sector to overweight. Land Securities and British Land are both higher. Panmure Gordon has upgraded its target price for Autonomy from 1693p to 1726p. FTSE 100 - RisersAutonomy Corporation (AU.) 1,501.00p +2.46%3i Group (III) 331.00p +2.38%British Land Co (BLND) 520.50p +2.26%Hammerson (HMSO) 425.80p +2.13%Amec (AMEC) 1,155.00p +2.12%TUI Travel (TT.) 239.70p +1.74%BT Group (BT.A) 182.30p +1.62%Man Group (EMG) 291.70p +1.46%Wolseley (WOS) 1,963.00p +1.39%Scottish & Southern Energy (SSE) 1,188.00p +1.28%FTSE 100 - FallersAstraZeneca (AZN) 2,984.50p -5.34%Royal Bank of Scotland Group (RBS) 39.15p -2.42%Lloyds Banking Group (LLOY) 67.60p -1.97%Serco Group (SRP) 586.00p -1.84%Resolution Ltd. (RSL) 231.60p -1.66%United Utilities Group (UU.) 585.50p -1.43%Sage Group (SGE) 275.70p -1.32%Barclays (BARC) 260.20p -1.25%Aggreko (AGK) 1,490.00p -1.13%BP (BP.) 464.90p -1.09%