Pharmaceuticals firm Shire was the biggest blue-chip faller after it withdrew its licence application for the Fabry disease treatment, REPLAGAL, with the US Food and Drug Administration (FDA).Richard Brasher, the head of Tesco's UK operations, is to quit after only a year in the job, sending the stock plummeting.The move comes after Group Chief Executive Officer, Philip Clarke, said he would "take a much closer involvement in the UK business" following the supermarket firm's first profit warning in 20 years. Heading in the other direction, although not enough to take it into the top 10, was power systems developer Rolls-Royce, which has announced another big contract win, this time to design and equip four deep-water platform supply vessels for Hyundai. The contract is worth more than £45m to Rolls-Royce and includes options for a further two of the vessels, which are designed to supply equipment and services to deep-water oil and gas platforms. Miners were also recovering after yesterday's losses as metal floor prices climbed higher, with the exception of gold. Kazakhyms, Vedanta and Rio Tinto were all making strong gains, while Randgold Resources took a hit. FTSE 100 - RisersNext (NXT) 2,893.00p +2.33%Kazakhmys (KAZ) 961.00p +1.85%Essar Energy (ESSR) 114.10p +1.51%BHP Billiton (BLT) 2,025.50p +1.25%Lloyds Banking Group (LLOY) 35.89p +1.23%Vedanta Resources (VED) 1,408.00p +1.22%Rio Tinto (RIO) 3,519.50p +1.14%ICAP (IAP) 407.10p +1.02%Carnival (CCL) 2,040.00p +0.99%Rexam (REX) 427.50p +0.90%FTSE 100 - FallersShire Plc (SHP) 2,180.00p -2.15%Royal Bank of Scotland Group (RBS) 26.03p -2.00%Randgold Resources Ltd. (RRS) 6,730.00p -1.75%ITV (ITV) 86.75p -1.25%InterContinental Hotels Group (IHG) 1,467.00p -1.21%BT Group (BT.A) 215.40p -1.19%Tesco (TSCO) 321.00p -1.19%Whitbread (WTB) 1,698.00p -1.16%SABMiller (SAB) 2,614.50p -1.15%Sainsbury (J) (SBRY) 299.20p -1.09%NR