(ShareCast News) - With Shire shares almost £20 short of last year's all-time high, the drug developer's chairwoman, chief executive and a clutch of senior directors have splashed some cash to show what they think of the valuation.Seven board members put their money where their mouths were, having last Thursday posted fourth quarter sales that beat forecasts and issued much stronger guidance for 2016.Chair Susan Kilsby shelled out almost $254,000 on 1,600 American Depositary Shares (ADS) late on Friday at $158.41 apiece.With one ADS equal to three ordinary shares, that meant she bought at around $52.8 per share or £36.56.CEO Flemming Ornskov forked out over $200,000 on 1,300 ADS at $154.12, while non-executives Steven Gillis and Olivier Bohuon spent $48,000 and £35,500, following purchases from fellow independent directors Anne Minto and Bill Burns earlier on Friday, as well as recently appointed general counsel Bill Mordan.For 2016, Shire is now targeting double digit top-line growth and a 7%-10% increase in earnings before even including the effect of its takeover of Baxalta.On Monday, even after trimming its price target to take effect of sector-wide compressed multiples and lower profits, broker Jefferies set a target price for Shire's shares of 5,150p and reiterated its 'buy' recommendation.Top Director BuysDatatec Ltd. (di) (DTC)Director name: Seabrooke,Christopher SAmount purchased: 198,618 @ R40.54Value: R363,291.80Canaccord Genuity Group Inc. (CF.)Director name: Daviau,DanielAmount purchased: 98,000 @ $3.67Value: $253,704.74Shire Plc (SHP)Director name: Kilsby,SusanAmount purchased: 4,800 @ $52.80Value: $178,607.17Shire Plc (SHP)Director name: Ornskov,FlemmingAmount purchased: 3,900 @ $51.37Value: $141,184.35Pennon Group (PNN)Director name: McAulay ,Ian Amount purchased: 9,703 @ 835.48pValue: £81,066.63Paypoint (PAY)Director name: Carson,Neil A PAmount purchased: 10,000 @ 737.89pValue: £73,789.00First Property Group (FPO)Director name: Digby,George R WAmount purchased: 148,456 @ 48.52pValue: £72,030.85Fidessa Group (FDSA)Director name: Hamer,JohnAmount purchased: 3,000 @ 1,877.40pValue: £56,322.00Enterprise Inns (ETI)Director name: Walker,Robert MAmount purchased: 67,000 @ 75.07pValue: £50,298.28Shire Plc (SHP)Director name: Bohuon,OlivierAmount purchased: 1,000 @ 3,552.12pValue: £35,521.20Shire Plc (SHP)Director name: Gillis,StevenAmount purchased: 930 @ $51.59Value: $33,809.22Canaccord Genuity Group Inc. (CF.)Director name: Daviau,DanielAmount purchased: 12,000 @ $3.67Value: $31,065.89Land Securities Group (LAND)Director name: Bartram,ChristopherAmount purchased: 3,000 @ 995.40pValue: £29,862.01Hammerson (HMSO)Director name: Atkins,DavidAmount purchased: 5,000 @ 561.40pValue: £28,070.00Hammerson (HMSO)Director name: Tyler,David AAmount purchased: 5,000 @ 558.40pValue: £27,920.00Paypoint (PAY)Director name: Barr,GillAmount purchased: 2,595 @ 728.00pValue: £18,891.60Strat Aero (AERO)Director name: Dunleavy ,Tony Amount purchased: 250,000 @ 4.25pValue: £10,625.00Pinnacle Technology Group (PINN)Director name: Duckworth,Simon D'OlierAmount purchased: 100,000 @ 8.00pValue: £8,000.00Fidessa Group (FDSA)Director name: Hamer,JohnAmount purchased: 140 @ 1,862.12pValue: £2,606.97Speedy Hire (SDY)Director name: Down,RussellAmount purchased: 1,276 @ 34.18pValue: £436.14Mortgage Advice Bureau (holdings) (MAB1)Director name: Tilley,LucyAmount purchased: 96 @ 312.00pValue: £299.52Go-ahead Group (GOG)Director name: Brown,David Amount purchased: 7 @ 2,185.00pValue: £152.95Aa (AA.)Director name: Mackenzie,BobAmount purchased: 58 @ 260.00pValue: £150.80Aa (AA.)Director name: Clarke,Martin CAmount purchased: 58 @ 260.00pValue: £150.80Alternative Networks (AN.)Director name: Griggs,Gavin Amount purchased: 35 @ 429.00pValue: £150.15Alternative Networks (AN.)Director name: Quartermaine,Mark Amount purchased: 35 @ 429.00pValue: £150.15Balfour Beatty (BBY)Director name: Quinn,LeoAmount purchased: 66 @ 224.79pValue: £148.36Mitchells & Butlers (MAB)Director name: Jones,Timothy (Tim) CharlesAmount purchased: 52 @ 263.48pValue: £137.01Kcom Group (KCOM)Director name: Simpson,PaulAmount purchased: 117 @ 107.50pValue: £125.78Go-ahead Group (GOG)Director name: Edwards,Paul Amount purchased: 5 @ 2,185.00pValue: £109.25Go-ahead Group (GOG)Director name: Ferguson,CarolynAmount purchased: 7 @ n/aValue: n/aTop Director SellsFirst Property Group (FPO)Director name: Digby,George R WAmount purchased: 148,456 @ 48.50pValue: £72,001.16